Compare the teams' outright winning chances, recent form and value in the match-winner market.
Penrith bring the stronger season record into Round 26, while Canterbury's recent defence and second-phase attack give the Bulldogs a route into the contest.
See how the handicap changes the matchup and whether either side offers cover value.
Penrith are strong favourites in Round 26, but Canterbury's recent competitiveness makes the market line of Panthers -9.5 the key betting question at CommBank Stadium.
Assess the scoring outlook against the bookmaker's combined-points line.
Two strong recent defensive records put the 40.5 point total under pressure despite enough attacking quality on both sides to keep the market finely balanced.